Cytochrome P450IIE1 is involved in the metabolic activation of many xenobiotics involved with human toxicity. In particular, cellular concentrations of P450IIE1 are significantly induced by the most widely abused drug in our society today, alcohol. As a result, the synthesis and degradation of this form of P450 has significant health consequences. The regulation of the steady‐state concentration of P450IIE1 is an extremely complex process. The enzyme is regulated by transcriptional activation, mRNA stabilization, increased mRNA translatability and decreased protein degradation. The (...) principal mechanism which controls the induction process depends on the chemical nature of the inducer, the age, and the nutritional and hormonal status of the animal. There also appear to be significant sex differences in the expression of P450IIE1. It is entirely possible that the regulation of the enzyme concentration under any given set of conditions will involve all of the mechanisms to different extents. (shrink)

We address the ethics of scenarios in which one party entraps, intentionally tempts or intentionally tests the virtue of another. We classify, in a new manner, three distinct types of acts that are of concern, namely acts of entrapment, of intentional temptation and of virtue testing. Our classification is, for each kind of scenario, of itself neutral concerning the question whether the agent acts permissibly. We explain why acts of entrapment are more ethically objectionable than like acts of intentional temptation (...) and why these, in turn, are more ethically objectionable than like acts of virtue testing. Along the way, we scrutinize, and eventually reject, the view that acts of entrapment are ethically unacceptable because intentional temptation is involved in entrapment. (shrink)

Fleming, Daniel J; Ryan, Thomas Three recent phrases of Pope Francis warrant attention and guide this article. First, there is his call for 'witnesses of God's love' in his tribute to modern martyrs. The second is 'the pedagogy of grace' and the work of the Spirit explained in 'Amoris Laetitia'. Third, from the same document, we find his discussion of accompaniment in the process of moral discernment within the church. With these as guideposts and drawing on recent studies in (...) moral philosophy and psychology, this article unfolds in five steps: setting the scene; witness in relation to moral understanding and intersubjectivity; intersubjectivity and conscience; a pedagogy of grace: Holy Spirit and nonbelievers; and a pedagogy of grace in relation to moral development. (shrink)

No detailed description available for "Language in the Philosophy of Hegel".

Faith plays a valuable role in sustaining relationships through various kinds of challenges, including through evidentially unfavorable circumstances and periods of significant doubt. But if, as is widely assumed, both faith in God and faith that God exists require belief that God exists, and if one’s beliefs are properly responsive to one’s evidence, the capacity for faith to persevere amidst significant and well-grounded doubt will be fairly limited. Taking Mother Teresa as an exemplar of Christian faith and exploring the close (...) connection between faith and faithfulness in the context of committed covenantal relationships, I set out a view of Relational Faith that does not assume that faith requires belief and allows wide room for honestly wrestling with doubt from within the Judeo-Christian tradition. (shrink)

Edward Stuart Russell (1887–1954) was a central figure in the philosophy of biology during the first half of the twentieth century. Although he worked as a government fisheries scientist for much of his life, he still managed to establish himself as one of the most prominent biological theorists of his time. The views he developed, which were antireductionistic, organism-centred, and teleological, challenged the prevailing mechanistic orthodoxy. His book 'The Interpretation of Development and Heredity' (1930) provides one of themost incisive critiques (...) of the chromosomal theory of the gene ever published, and it has acquired a renewed relevance in light of recent empirical findings. Russell’s interest in the theoretical problems of biology is as much historical as philosophical, and many of his works, particularly his first book 'Form and Function' (1916), are still regarded today as landmark contributions to the history of biological thought. (shrink)

The ultimate goal of the pioneering project outlined in this book is to map our genome--the key to what makes us human--in detail. The Code of Codes is a collective exploration of the substance and possible consequences of th is project in relation to ethics, law, and society.

Examines how globalization, technology, community, gender, identity, family, and the environment will change over the next century.

Jaakko Hintikka (1998) has argued that clarifying the notion of abduction is the fundamental problem of contemporary epistemology. One traditional interpretation of Peirce on abduction sees it as a recipe for generating new theoretical discoveries . A second standard view sees abduction as a mode of reasoning that justifies beliefs about the probable truth of theories. While each reading has some grounding in Peirce's writings, each leaves out features that are crucial to Peirce's distinctive understanding of abduction. I develop and (...) defend a third interpretation, according to which Peirce takes abductive reasoning to lead to judgments about the relative pursuitworthiness of theories; conclusions that can be thoroughly disconnected from assessments of truth-value. Even if Peirce's use of "abduction" slides around among each of these three importantly different though potentially compatible senses, this neglected third understanding makes sense of a large number of Peirce's remarks and directs our attention to the cognitive structure of judgments that scientists face after the initial proposal of explanatory hypotheses but prior to their experimental testing; a topic which should be of interest to contemporary philosophers of science. (shrink)

Answering the call of the Second Vatican Council for moral theology to 'draw more fully on the teaching of Holy Scripture, ' the authors examine the virtues that both flow from Scripture and provide a lens by which to interpret Scripture.

Since at least the mid-2000s, political commentators, environmental advocates, and scientists have raised concerns about an “anti-science” approach to environmental policymaking in conservative governments in the US and Canada. This paper explores and resolves a paradox surrounding at least some uses of the “anti-science” epithet. I examine two cases of such “anti-science” environmental policy, both of which involve appeals to epistemic values that are widely endorsed by both scientists and philosophers of science. It seems paradoxical to call an appeal to (...) epistemic values “anti-science.” I develop an analysis that, I argue, can resolve this paradox. This analysis is a version of the “aims approach” to science and values, drawing on ideas from axiology and virtue ethics. I characterize the paradox in terms of conflicts or tensions between epistemic and pragmatic aims, and argue that there is a key asymmetry between them: epistemic aims are valuable, in part, because they are useful for pursuing pragmatic aims. Thus, when epistemic and pragmatic aims conflict, epistemic aims need to be reconceptualized in order to reconcile them to pragmatic aims. When this is done, in the “anti-science” cases, the epistemic values are scientific vices rather than virtues. Thus the “anti-science” epithet is apt. (shrink)

There is a puzzle about Hume's is-ought gap involving an epistemic `ought'. From the premise `Snow is white,' we can infer `Sophia's belief that snow is white is correct.' `Snow is white' is paradigmatically non-normative, and that Sophia's belief is correct, a claim about what belief she ought to have, seems to be normative. The argument seems valid, so the is-ought gap is supposed to block this kind of inference. The puzzle is over whether we should give up on the (...) is-ought game or find another way to resolve the conflict. In the first chapter, I provide a formulation of the is-ought gap in a general semantic framework that avoids some other known problems. I turn in chapter 2 to discussing the puzzle about correct belief. I cast doubt on a solution proposed by Allan Gibbard by showing that it can admit of no epistemology of the normative. In chapter 3, I defend a solution to the puzzle while more directly tackling the question of the nature of oughts for belief. I offer a new explanation of why we ought to believe the truth. At the heart of the account is the idea that it's a conceptual truth beliefs ought to be true, which I provide a new argument for. I then claim that being an agent requires being subject to this norm of belief. This results in a non-moral, distinctly doxastic, account of why we ought to believe the truth. My conclusion is that asking why we ought to believe the truth is like asking why a bachelor must be unmarried: the answer is contained in the ideas that make up the question. In the final chapter, I respond to Gibbard's claim that an analogous story cannot work for `ought' claims for degreed belief. I pose a worry for Gibbard's proposed alternative explanation, and I undermine Gibbard's motivation for pursuing such an account in the first place. By taking belief to have an aim in a normative sense, I sketch how we can make sense of epistemic rationality in terms of that aim. (shrink)

ABSTRACTRecent rejections of epistemic consequentialism, like those from Firth, Jenkins, Berker, and Greaves, have argued that consequentialism is committed to objectionable trade-offs and suggest...

Many manipulation arguments against compatibilism rely on the claim that manipulation is relevantly similar to determinism. But we argue that manipulation is nothing like determinism in one relevant respect. Determinism is a "universal" phenomenon: its scope includes every feature of the universe. But manipulation arguments feature cases where an agent is the only manipulated individual in her universe. Call manipulation whose scope includes at least one but not all agents "existential manipulation." Our responsibility practices are impacted in different ways by (...) universal and existential phenomena. And this is a relevant difference, especially on Strawsonian approaches to moral responsibility, which take facts about our responsibility practices to be deeply connected to the nature of responsibility itself. We argue that Strawsonian accounts of moral responsibility are immune to manipulation arguments, and no attempt to modify the scope of manipulation or determinism featured in these arguments will help incompatibilists secure their desired conclusion. (shrink)

Since the 1970s, a sea change has marked the politics of science in the United States. In the quarter century after World War II, a broad, bipartisan consensus prevailed on the promotion and uses of science in American society: first, that the federal government should support research and training in technically meritorious fields of likely long-term benefit to national defense, the economy, and health; second, that the benefits of this investment should be developed into useful products by the private sector; (...) and that public policy in technically related areas should be shaped by drawing on highly qualified, non-partisan expertise. Since the 1970s, that bipartisan consensus has corroded, ushering in a New Politics of Science in the U.S. Ideological restrictions, largely from the political right, have prohibited or severely constricted federal support of research in areas such as human therapeutic cloning, human stem cells, in vitro fertilization, and human embryo research. The devotion to privatization and entrepreneurship in the name of high technology competitiveness has, in areas such as biotechnology, blurred the lines both intellectually and institutionally between academia and industry, with questionable consequences for the public interest. And nonpartisanship in the scientific advisory system has been succeeded by unashamed partisanship, fueled by the mobilization of expertise on the right in issues ranging from the teaching of evolution in the schools to global warming. The reasons for this sea change can be found in the larger rightward shift over the period on both the foreign and domestic fronts. (shrink)

Popular discussions of faith often assume that having faith is a form of believing on insufficient evidence and that having faith is therefore in some way rationally defective. Here I offer a characterization of action-centered faith and show that action-centered faith can be both epistemically and practically rational even under a wide variety of subpar evidential circumstances.

This collection of essays explores the metaphysical thesis that the living world is not made up of substantial particles or things, as has often been assumed, but is rather constituted by processes. The biological domain is organised as an interdependent hierarchy of processes, which are stabilised and actively maintained at different timescales. Even entities that intuitively appear to be paradigms of things, such as organisms, are actually better understood as processes. Unlike previous attempts to articulate processual views of biology, which (...) have tended to use Alfred North Whitehead’s panpsychist metaphysics as a foundation, this book takes a naturalistic approach to metaphysics. It submits that the main motivations for replacing an ontology of substances with one of processes are to be found in the empirical findings of science. Biology provides compelling reasons for thinking that the living realm is fundamentally dynamic, and that the existence of things is always conditional on the existence of processes. The phenomenon of life cries out for theories that prioritise processes over things, and it suggests that the central explanandum of biology is not change but rather stability, or more precisely, stability attained through constant change. This edited volume brings together philosophers of science and metaphysicians interested in exploring the consequences of a processual philosophy of biology. The contributors draw on an extremely wide range of biological case studies, and employ a process perspective to cast new light on a number of traditional philosophical problems, such as identity, persistence, and individuality. (shrink)

The Computational History of Philosophy of Science Dataset aims to be a comprehensive set of article and book chapter metadata for philosophy of science. The dataset covers the full run of over 40 journals and 3 major book series in the field. An automated author disambiguation script is used to construct canonical names for each author, and a combination of gender attribution methods is used to attribute the gender of each author. The full code used to generate the dataset is (...) available at [URL not allowed]. See the file data_dictionary.txt for data dictionary and additional information. (shrink)

People often fail to detect large changes to scenes, provided that the changes occur during a visual disruption. This phenomenon, known as ''change blindness,'' occurs both in the laboratory and in real-world situations in which changes occur unexpectedly. The pervasiveness of the inability to detect changes is consistent with the theoretical notion that we internally represent relatively little information from our visual world from one glance at a scene to the next. However, evidence for change blindness does not necessarily imply (...) the absence of such a representation-people could also miss changes if they fail to compare an existing representation of the pre-change scene to the post-change scene. In three experiments, we show that people often do have a representation of some aspects of the pre-change scene even when they fail to report the change. And, in fact, they appear to ''discover'' this memory and can explicitly report details of a changed object in response to probing questions. The results of these real-world change detection studies are discussed in the context of broader claims about change blindness. (shrink)

The impact of Niels Bohr’s 1932 “Light and Life” lecture on Max Delbrück’s lifelong search for a form of “complementarity” in biology is well documented and much discussed, but the precise nature of that influence remains subject to misunderstanding. The standard reading, which sees Delbrück’s transition from physics into biology as inspired by the hope that investigation of biological phenomena might lead to a breakthrough discovery of new laws of physics, is colored much more by Erwin Schrödinger’s What Is Life? (...) than is often acknowledged. Bohr’s view was that teleological and mechanistic descriptions are mutually exclusive yet jointly necessary for an exhaustive understanding of life. Although Delbrück’s approach was empirical and less self‐consciously philosophical, he shared Bohr’s hope that scientific investigation would vindicate the view that at least some aspects of life are not reducible to physico‐chemical terms. (shrink)

From an early age, humans know a surprising amount about basic physical principles, such as gravity, force, mass, and shape. We can see this in the way that young children play, and manipulate objects around them. The same behaviour has long been observed in primates - chimpanzees have been shown to possess a remarkable ability to make and use simple tools. But what does this tell us about their inner mental state - do they therefore share the same understanding to (...) that of a young child? Do they understand the simple, underlying physical principles involved? Though some people would say that they do, this book reports groundbreaking research that questions whether this really is the case. -/- Folk Physics for Apes challenges the assumptions so often made about apes. It offers us a rare glimpse into the workings of another mind, examining how apes perceive and understand the physical world - an understanding that appears to be both similar to, and yet profoundly different from our own. The book will have broad appeal to evolutionary psychologists, developmental psychologists, and those interested in the sub-disciplines of cognitive science (philosophy, anthropology). The book additionally offers for developmental psychologists some valuable new non-verbal techniques for assessing causal understanding in young children. (shrink)

Many mathematics students have trouble the first time they take a course, such as linear algebra, abstract algebra, introductory analysis, or discrete mathematics, in which they are asked to prove various theorems. This textbook will prepare students to make the transition from solving problems to proving theorems by teaching them the techniques needed to read and write proofs. The book begins with the basic concepts of logic and set theory, to familiarize students with the language of mathematics and how it (...) is interpreted. These concepts are used as the basis for a step-by-step breakdown of the most important techniques used in constructing proofs. The author shows how complex proofs are built up from these smaller steps, using detailed "scratchwork" sections to expose the machinery of proofs about the natural numbers, relations, functions, and infinite sets. Numerous exercises give students the opportunity to construct their own proofs. No background beyond standard high school mathematics is assumed. This book will be useful to anyone interested in logic and proofs: computer scientists, philosophers, linguists, and of course mathematicians. (shrink)